diff --git a/cli/server/server.go b/cli/server/server.go
index 5f80bf42b..e864642d4 100644
--- a/cli/server/server.go
+++ b/cli/server/server.go
@@ -538,6 +538,10 @@ Main:
 				log.Warn("ProtocolConfiguration changed, signal ignored")
 				break // Continue working.
 			}
+			if !cfg.ApplicationConfiguration.EqualsButServices(&cfgnew.ApplicationConfiguration) {
+				log.Warn("ApplicationConfiguration changed in incompatible way, signal ignored")
+				break // Continue working.
+			}
 			switch sig {
 			case syscall.SIGHUP:
 				rpcServer.Shutdown()
diff --git a/pkg/config/application_config.go b/pkg/config/application_config.go
index cbf7be3d1..ac6db77af 100644
--- a/pkg/config/application_config.go
+++ b/pkg/config/application_config.go
@@ -29,3 +29,25 @@ type ApplicationConfiguration struct {
 	// ExtensiblePoolSize is the maximum amount of the extensible payloads from a single sender.
 	ExtensiblePoolSize int `yaml:"ExtensiblePoolSize"`
 }
+
+// EqualsButServices returns true when the o is the same as a except for services
+// (Oracle, P2PNotary, Pprof, Prometheus, RPC, StateRoot and UnlockWallet sections).
+func (a *ApplicationConfiguration) EqualsButServices(o *ApplicationConfiguration) bool {
+	if a.Address != o.Address ||
+		a.AnnouncedNodePort != o.AnnouncedNodePort ||
+		a.AttemptConnPeers != o.AttemptConnPeers ||
+		a.DBConfiguration != o.DBConfiguration ||
+		a.DialTimeout != o.DialTimeout ||
+		a.ExtensiblePoolSize != o.ExtensiblePoolSize ||
+		a.LogPath != o.LogPath ||
+		a.MaxPeers != o.MaxPeers ||
+		a.MinPeers != o.MinPeers ||
+		a.NodePort != o.NodePort ||
+		a.PingInterval != o.PingInterval ||
+		a.PingTimeout != o.PingTimeout ||
+		a.ProtoTickInterval != o.ProtoTickInterval ||
+		a.Relay != o.Relay {
+		return false
+	}
+	return true
+}
diff --git a/pkg/config/application_config_test.go b/pkg/config/application_config_test.go
new file mode 100644
index 000000000..8b5428e8f
--- /dev/null
+++ b/pkg/config/application_config_test.go
@@ -0,0 +1,22 @@
+package config
+
+import (
+	"path/filepath"
+	"testing"
+
+	"github.com/stretchr/testify/require"
+)
+
+func TestApplicationConfigurationEquals(t *testing.T) {
+	a := &ApplicationConfiguration{}
+	o := &ApplicationConfiguration{}
+	require.True(t, a.EqualsButServices(o))
+	require.True(t, o.EqualsButServices(a))
+	require.True(t, a.EqualsButServices(a))
+
+	cfg1, err := LoadFile(filepath.Join("..", "..", "config", "protocol.mainnet.yml"))
+	require.NoError(t, err)
+	cfg2, err := LoadFile(filepath.Join("..", "..", "config", "protocol.testnet.yml"))
+	require.NoError(t, err)
+	require.False(t, cfg1.ApplicationConfiguration.EqualsButServices(&cfg2.ApplicationConfiguration))
+}