diff --git a/cmd/neofs-node/config/engine/config_test.go b/cmd/neofs-node/config/engine/config_test.go
index e3a73766..fd4df9af 100644
--- a/cmd/neofs-node/config/engine/config_test.go
+++ b/cmd/neofs-node/config/engine/config_test.go
@@ -70,6 +70,7 @@ func TestEngineSection(t *testing.T) {
 				require.Equal(t, "tmp/0/blob", blob.Path())
 				require.EqualValues(t, 0644, blob.Perm())
 				require.Equal(t, true, blob.Compress())
+				require.Equal(t, []string{"audio/*", "video/*"}, blob.UncompressableContentTypes())
 				require.EqualValues(t, 5, blob.ShallowDepth())
 				require.EqualValues(t, 102400, blob.SmallSizeLimit())
 
@@ -99,6 +100,7 @@ func TestEngineSection(t *testing.T) {
 				require.Equal(t, "tmp/1/blob", blob.Path())
 				require.EqualValues(t, 0644, blob.Perm())
 				require.Equal(t, false, blob.Compress())
+				require.Equal(t, []string(nil), blob.UncompressableContentTypes())
 				require.EqualValues(t, 5, blob.ShallowDepth())
 				require.EqualValues(t, 102400, blob.SmallSizeLimit())
 
diff --git a/cmd/neofs-node/config/engine/shard/blobstor/config.go b/cmd/neofs-node/config/engine/shard/blobstor/config.go
index 51c380ce..f3e3924b 100644
--- a/cmd/neofs-node/config/engine/shard/blobstor/config.go
+++ b/cmd/neofs-node/config/engine/shard/blobstor/config.go
@@ -88,6 +88,15 @@ func (x *Config) Compress() bool {
 	)
 }
 
+// UncompressableContentTypes returns value of "compress_skip_content_types" config parameter.
+//
+// Returns nil if a value is missing or is invalid.
+func (x *Config) UncompressableContentTypes() []string {
+	return config.StringSliceSafe(
+		(*config.Config)(x),
+		"compression_exclude_content_types")
+}
+
 // SmallSizeLimit returns value of "small_object_size" config parameter.
 //
 // Returns SmallSizeLimitDefault if value is not a positive number.
diff --git a/config/example/node.env b/config/example/node.env
index 0ee9b286..f241817c 100644
--- a/config/example/node.env
+++ b/config/example/node.env
@@ -90,6 +90,7 @@ NEOFS_STORAGE_SHARD_0_METABASE_PERM=0644
 NEOFS_STORAGE_SHARD_0_BLOBSTOR_PATH=tmp/0/blob
 NEOFS_STORAGE_SHARD_0_BLOBSTOR_PERM=0644
 NEOFS_STORAGE_SHARD_0_BLOBSTOR_COMPRESS=true
+NEOFS_STORAGE_SHARD_0_BLOBSTOR_COMPRESSION_EXCLUDE_CONTENT_TYPES="audio/* video/*"
 NEOFS_STORAGE_SHARD_0_BLOBSTOR_DEPTH=5
 NEOFS_STORAGE_SHARD_0_BLOBSTOR_SMALL_OBJECT_SIZE=102400
 ### Blobovnicza config
diff --git a/config/example/node.json b/config/example/node.json
index ca8b8112..7c288739 100644
--- a/config/example/node.json
+++ b/config/example/node.json
@@ -136,6 +136,9 @@
           "path": "tmp/0/blob",
           "perm": "0644",
           "compress": true,
+          "compression_exclude_content_types": [
+            "audio/*", "video/*"
+          ],
           "depth": 5,
           "small_object_size": 102400,
           "blobovnicza": {
diff --git a/config/example/node.yaml b/config/example/node.yaml
index 69e5f846..217d81b0 100644
--- a/config/example/node.yaml
+++ b/config/example/node.yaml
@@ -146,6 +146,9 @@ storage:
       blobstor:
         path: tmp/0/blob  # blobstor path
         compress: true  # turn on/off zstd(level 3) compression of stored objects
+        compression_exclude_content_types:
+          - audio/*
+          - video/*
 
       gc:
         remover_batch_size: 150  # number of objects to be removed by the garbage collector
diff --git a/pkg/local_object_storage/blobstor/blobovnicza_test.go b/pkg/local_object_storage/blobstor/blobovnicza_test.go
index 0b2d9af7..76a96b80 100644
--- a/pkg/local_object_storage/blobstor/blobovnicza_test.go
+++ b/pkg/local_object_storage/blobstor/blobovnicza_test.go
@@ -31,7 +31,7 @@ func testAddress() *objectSDK.Address {
 	return addr
 }
 
-func testObject(sz uint64) *object.Object {
+func testObjectRaw(sz uint64) *object.RawObject {
 	raw := object.NewRaw()
 
 	addr := testAddress()
@@ -46,7 +46,11 @@ func testObject(sz uint64) *object.Object {
 		raw.SetPayload(raw.Payload()[:sz-(ln-sz)])
 	}
 
-	return raw.Object()
+	return raw
+}
+
+func testObject(sz uint64) *object.Object {
+	return testObjectRaw(sz).Object()
 }
 
 func TestBlobovniczas(t *testing.T) {
diff --git a/pkg/local_object_storage/blobstor/blobstor.go b/pkg/local_object_storage/blobstor/blobstor.go
index 395c85a8..5c927b07 100644
--- a/pkg/local_object_storage/blobstor/blobstor.go
+++ b/pkg/local_object_storage/blobstor/blobstor.go
@@ -28,6 +28,8 @@ type cfg struct {
 
 	compressionEnabled bool
 
+	uncompressableContentTypes []string
+
 	compressor func([]byte) []byte
 
 	decompressor func([]byte) ([]byte, error)
@@ -117,6 +119,14 @@ func WithCompressObjects(comp bool) Option {
 	}
 }
 
+// WithUncompressableContentTypes returns option to disable decompression
+// for specific content types as seen by object.AttributeContentType attribute.
+func WithUncompressableContentTypes(values []string) Option {
+	return func(c *cfg) {
+		c.uncompressableContentTypes = values
+	}
+}
+
 // WithRootPath returns option to set path to root directory
 // of the fs tree to write the objects.
 func WithRootPath(rootDir string) Option {
diff --git a/pkg/local_object_storage/blobstor/blobstor_test.go b/pkg/local_object_storage/blobstor/blobstor_test.go
index 9af7956e..df614e4e 100644
--- a/pkg/local_object_storage/blobstor/blobstor_test.go
+++ b/pkg/local_object_storage/blobstor/blobstor_test.go
@@ -5,6 +5,7 @@ import (
 	"testing"
 
 	"github.com/nspcc-dev/neofs-node/pkg/core/object"
+	objectSDK "github.com/nspcc-dev/neofs-sdk-go/object"
 	"github.com/stretchr/testify/require"
 )
 
@@ -76,3 +77,65 @@ func TestCompression(t *testing.T) {
 	testGet(t, blobStor, 2)
 	require.NoError(t, blobStor.Close())
 }
+
+func TestBlobstor_needsCompression(t *testing.T) {
+	const smallSizeLimit = 512
+	newBlobStor := func(t *testing.T, compress bool, ct ...string) *BlobStor {
+		dir, err := os.MkdirTemp("", "neofs*")
+		require.NoError(t, err)
+		t.Cleanup(func() { _ = os.RemoveAll(dir) })
+
+		bs := New(WithCompressObjects(compress),
+			WithRootPath(dir),
+			WithSmallSizeLimit(smallSizeLimit),
+			WithBlobovniczaShallowWidth(1),
+			WithUncompressableContentTypes(ct))
+		require.NoError(t, bs.Open())
+		require.NoError(t, bs.Init())
+		return bs
+	}
+
+	newObjectWithCt := func(contentType string) *object.Object {
+		obj := testObjectRaw(smallSizeLimit + 1)
+		if contentType != "" {
+			a := objectSDK.NewAttribute()
+			a.SetKey(objectSDK.AttributeContentType)
+			a.SetValue(contentType)
+			obj.SetAttributes(a)
+		}
+		return obj.Object()
+	}
+
+	t.Run("content-types specified", func(t *testing.T) {
+		b := newBlobStor(t, true, "audio/*", "*/x-mpeg", "*/mpeg", "application/x-midi")
+
+		obj := newObjectWithCt("video/mpeg")
+		require.False(t, b.needsCompression(obj))
+
+		obj = newObjectWithCt("audio/aiff")
+		require.False(t, b.needsCompression(obj))
+
+		obj = newObjectWithCt("application/x-midi")
+		require.False(t, b.needsCompression(obj))
+
+		obj = newObjectWithCt("text/plain")
+		require.True(t, b.needsCompression(obj))
+
+		obj = newObjectWithCt("")
+		require.True(t, b.needsCompression(obj))
+	})
+	t.Run("content-types omitted", func(t *testing.T) {
+		b := newBlobStor(t, true)
+		obj := newObjectWithCt("video/mpeg")
+		require.True(t, b.needsCompression(obj))
+	})
+	t.Run("compress disabled", func(t *testing.T) {
+		b := newBlobStor(t, false, "video/mpeg")
+
+		obj := newObjectWithCt("video/mpeg")
+		require.False(t, b.needsCompression(obj))
+
+		obj = newObjectWithCt("text/plain")
+		require.False(t, b.needsCompression(obj))
+	})
+}
diff --git a/pkg/local_object_storage/blobstor/iterate_test.go b/pkg/local_object_storage/blobstor/iterate_test.go
index e300f1b7..49bd0fca 100644
--- a/pkg/local_object_storage/blobstor/iterate_test.go
+++ b/pkg/local_object_storage/blobstor/iterate_test.go
@@ -66,7 +66,7 @@ func TestIterateObjects(t *testing.T) {
 	}
 
 	for _, v := range mObjs {
-		_, err := blobStor.PutRaw(v.addr, v.data)
+		_, err := blobStor.PutRaw(v.addr, v.data, true)
 		require.NoError(t, err)
 	}
 
diff --git a/pkg/local_object_storage/blobstor/put.go b/pkg/local_object_storage/blobstor/put.go
index 50757344..c72b4455 100644
--- a/pkg/local_object_storage/blobstor/put.go
+++ b/pkg/local_object_storage/blobstor/put.go
@@ -2,7 +2,9 @@ package blobstor
 
 import (
 	"fmt"
+	"strings"
 
+	"github.com/nspcc-dev/neofs-node/pkg/core/object"
 	storagelog "github.com/nspcc-dev/neofs-node/pkg/local_object_storage/internal/log"
 	objectSDK "github.com/nspcc-dev/neofs-sdk-go/object"
 )
@@ -32,15 +34,43 @@ func (b *BlobStor) Put(prm *PutPrm) (*PutRes, error) {
 		return nil, fmt.Errorf("could not marshal the object: %w", err)
 	}
 
-	return b.PutRaw(prm.obj.Address(), data)
+	return b.PutRaw(prm.obj.Address(), data, b.needsCompression(prm.obj))
+}
+
+func (b *BlobStor) needsCompression(obj *object.Object) bool {
+	if !b.compressionEnabled || len(b.uncompressableContentTypes) == 0 {
+		return b.compressionEnabled
+	}
+
+	for _, attr := range obj.Attributes() {
+		if attr.Key() == objectSDK.AttributeContentType {
+			for _, value := range b.uncompressableContentTypes {
+				match := false
+				switch {
+				case len(value) > 0 && value[len(value)-1] == '*':
+					match = strings.HasPrefix(attr.Value(), value[:len(value)-1])
+				case len(value) > 0 && value[0] == '*':
+					match = strings.HasSuffix(attr.Value(), value[1:])
+				default:
+					match = attr.Value() == value
+				}
+				if match {
+					return false
+				}
+			}
+		}
+	}
+
+	return b.compressionEnabled
 }
 
 // PutRaw saves already marshaled object in BLOB storage.
-func (b *BlobStor) PutRaw(addr *objectSDK.Address, data []byte) (*PutRes, error) {
+func (b *BlobStor) PutRaw(addr *objectSDK.Address, data []byte, compress bool) (*PutRes, error) {
 	big := b.isBig(data)
 
-	// compress object data
-	data = b.compressor(data)
+	if compress {
+		data = b.compressor(data)
+	}
 
 	if big {
 		// save object in shallow dir
diff --git a/pkg/local_object_storage/writecache/flush.go b/pkg/local_object_storage/writecache/flush.go
index b2faf7a1..1684dfcc 100644
--- a/pkg/local_object_storage/writecache/flush.go
+++ b/pkg/local_object_storage/writecache/flush.go
@@ -125,7 +125,7 @@ func (c *cache) flushBigObjects() {
 					return nil
 				}
 
-				if _, err := c.blobstor.PutRaw(addr, data); err != nil {
+				if _, err := c.blobstor.PutRaw(addr, data, true); err != nil {
 					c.log.Error("cant flush object to blobstor", zap.Error(err))
 					return nil
 				}