diff --git a/README.md b/README.md
index e9fb583e4..73ed3ce53 100644
--- a/README.md
+++ b/README.md
@@ -144,6 +144,17 @@ If parameter doesn't support environment variable (e.g. `--listen_address 0.0.0.
 listen_address: 0.0.0.0:8084
 ```
 
+#### Cache parameters 
+
+Parameters for caches in s3-gw can be specified in .yaml config file. E.g.:
+```
+cache:
+  lifetime: 300s
+  size: 150
+  list_objects_lifetime: 1m
+```
+If invalid values are set, the gateway will use default values instead.
+
 ## NeoFS AuthMate
 
 Authmate is a tool to create gateway AWS credentials. AWS users
diff --git a/api/cache/object_cache.go b/api/cache/object_cache.go
index 58a871015..f7bcc244a 100644
--- a/api/cache/object_cache.go
+++ b/api/cache/object_cache.go
@@ -15,9 +15,9 @@ type ObjectsCache interface {
 }
 
 const (
-	// DefaultObjectsCacheLifetime is a default lifetime of objects in cache.
+	// DefaultObjectsCacheLifetime is a default lifetime of entries in objects' cache.
 	DefaultObjectsCacheLifetime = time.Minute * 5
-	// DefaultObjectsCacheSize is a default maximum number of objects in cache.
+	// DefaultObjectsCacheSize is a default maximum number of entries in objects' in cache.
 	DefaultObjectsCacheSize = 1e6
 )
 
diff --git a/api/layer/layer.go b/api/layer/layer.go
index cebd35364..556d1c4ef 100644
--- a/api/layer/layer.go
+++ b/api/layer/layer.go
@@ -30,6 +30,13 @@ type (
 		objCache     cache.ObjectsCache
 	}
 
+	// CacheConfig contains params for caches.
+	CacheConfig struct {
+		Lifetime            time.Duration
+		Size                int
+		ListObjectsLifetime time.Duration
+	}
+
 	// Params stores basic API parameters.
 	Params struct {
 		Pool    pool.Pool
@@ -130,12 +137,12 @@ const (
 
 // NewLayer creates instance of layer. It checks credentials
 // and establishes gRPC connection with node.
-func NewLayer(log *zap.Logger, conns pool.Pool) Client {
+func NewLayer(log *zap.Logger, conns pool.Pool, config *CacheConfig) Client {
 	return &layer{
 		pool:         conns,
 		log:          log,
-		listObjCache: newListObjectsCache(defaultObjectsListCacheLifetime),
-		objCache:     cache.New(cache.DefaultObjectsCacheSize, cache.DefaultObjectsCacheLifetime),
+		listObjCache: newListObjectsCache(config.ListObjectsLifetime),
+		objCache:     cache.New(config.Size, config.Lifetime),
 	}
 }
 
diff --git a/api/layer/object_list_cache.go b/api/layer/object_list_cache.go
index 229d02a1b..6ed174a9a 100644
--- a/api/layer/object_list_cache.go
+++ b/api/layer/object_list_cache.go
@@ -13,7 +13,7 @@ import (
 	request.
 
 	The cache is a map which has a key: cacheOptions struct and a value: list of objects. After putting a record we
-	start a timer (via time.AfterFunc) that removes the record after defaultObjectsListCacheLifetime value.
+	start a timer (via time.AfterFunc) that removes the record after DefaultObjectsListCacheLifetime value.
 
 	When we get a request from the user we just try to find the suitable and non-expired cache and then we return
 	the list of objects. Otherwise we send the request to NeoFS.
@@ -27,7 +27,8 @@ type (
 	}
 )
 
-const defaultObjectsListCacheLifetime = time.Second * 60
+// DefaultObjectsListCacheLifetime is a default lifetime of entries in cache of ListObjects.
+const DefaultObjectsListCacheLifetime = time.Second * 60
 
 type (
 	listObjectsCache struct {
diff --git a/cmd/s3-gw/app-settings.go b/cmd/s3-gw/app-settings.go
index 44441ebb2..85c75bf51 100644
--- a/cmd/s3-gw/app-settings.go
+++ b/cmd/s3-gw/app-settings.go
@@ -54,6 +54,11 @@ const ( // Settings.
 	cfgRequestTimeout = "request_timeout"
 	cfgRebalanceTimer = "rebalance_timer"
 
+	// Caching.
+	cfgObjectsCacheLifetime     = "cache.lifetime"
+	cfgCacheSize                = "cache.size"
+	cfgListObjectsCacheLifetime = "cache.list_objects_lifetime"
+
 	// MaxClients.
 	cfgMaxClientsCount    = "max_clients_count"
 	cfgMaxClientsDeadline = "max_clients_deadline"
diff --git a/cmd/s3-gw/app.go b/cmd/s3-gw/app.go
index a04066c56..0e22d0084 100644
--- a/cmd/s3-gw/app.go
+++ b/cmd/s3-gw/app.go
@@ -10,6 +10,7 @@ import (
 	"github.com/nspcc-dev/neo-go/pkg/crypto/keys"
 	"github.com/nspcc-dev/neofs-s3-gw/api"
 	"github.com/nspcc-dev/neofs-s3-gw/api/auth"
+	"github.com/nspcc-dev/neofs-s3-gw/api/cache"
 	"github.com/nspcc-dev/neofs-s3-gw/api/handler"
 	"github.com/nspcc-dev/neofs-s3-gw/api/layer"
 	"github.com/nspcc-dev/neofs-s3-gw/internal/wallet"
@@ -108,8 +109,10 @@ func newApp(ctx context.Context, l *zap.Logger, v *viper.Viper) *App {
 		l.Fatal("failed to create connection pool", zap.Error(err))
 	}
 
+	cacheCfg := getCacheOptions(v, l)
+
 	// prepare object layer
-	obj = layer.NewLayer(l, conns)
+	obj = layer.NewLayer(l, conns, cacheCfg)
 
 	// prepare auth center
 	ctr = auth.New(conns, key)
@@ -207,3 +210,45 @@ func (a *App) Server(ctx context.Context) {
 
 	close(a.webDone)
 }
+
+func getCacheOptions(v *viper.Viper, l *zap.Logger) *layer.CacheConfig {
+	cacheCfg := layer.CacheConfig{
+		ListObjectsLifetime: layer.DefaultObjectsListCacheLifetime,
+		Size:                cache.DefaultObjectsCacheSize,
+		Lifetime:            cache.DefaultObjectsCacheLifetime,
+	}
+
+	if v.IsSet(cfgObjectsCacheLifetime) {
+		lifetime := v.GetDuration(cfgObjectsCacheLifetime)
+		if lifetime <= 0 {
+			l.Error("invalid cache lifetime, using default value (in seconds)",
+				zap.Duration("value in config", lifetime),
+				zap.Duration("default", cacheCfg.Lifetime))
+		} else {
+			cacheCfg.Lifetime = lifetime
+		}
+	}
+
+	if v.IsSet(cfgCacheSize) {
+		size := v.GetInt(cfgCacheSize)
+		if size <= 0 {
+			l.Error("invalid cache size, using default value",
+				zap.Int("value in config", size),
+				zap.Int("default", cacheCfg.Size))
+		} else {
+			cacheCfg.Size = size
+		}
+	}
+
+	if v.IsSet(cfgListObjectsCacheLifetime) {
+		lifetime := v.GetDuration(cfgListObjectsCacheLifetime)
+		if lifetime <= 0 {
+			l.Error("invalid list objects cache lifetime, using default value (in seconds)",
+				zap.Duration("value in config", lifetime),
+				zap.Duration("default", cacheCfg.ListObjectsLifetime))
+		} else {
+			cacheCfg.ListObjectsLifetime = lifetime
+		}
+	}
+	return &cacheCfg
+}