diff --git a/pkg/vm/interop.go b/pkg/vm/interop.go
index e2288b793..8e83e0f11 100644
--- a/pkg/vm/interop.go
+++ b/pkg/vm/interop.go
@@ -1,6 +1,7 @@
 package vm
 
 import (
+	"errors"
 	"fmt"
 )
 
@@ -20,3 +21,32 @@ func runtimeNotify(vm *VM) error {
 	fmt.Printf("NEO-GO-VM (notify) > %s\n", item.Value())
 	return nil
 }
+
+// runtimeSerialize handles syscalls System.Runtime.Serialize and Neo.Runtime.Serialize.
+func runtimeSerialize(vm *VM) error {
+	item := vm.Estack().Pop()
+	data, err := serializeItem(item.value)
+	if err != nil {
+		return err
+	} else if len(data) > MaxItemSize {
+		return errors.New("too big item")
+	}
+
+	vm.Estack().PushVal(data)
+
+	return nil
+}
+
+// runtimeDeserialize handles syscalls System.Runtime.Deserialize and Neo.Runtime.Deserialize.
+func runtimeDeserialize(vm *VM) error {
+	data := vm.Estack().Pop().Bytes()
+
+	item, err := deserializeItem(data)
+	if err != nil {
+		return err
+	}
+
+	vm.Estack().Push(&Element{value: item})
+
+	return nil
+}
diff --git a/pkg/vm/serialization.go b/pkg/vm/serialization.go
new file mode 100644
index 000000000..5918745ef
--- /dev/null
+++ b/pkg/vm/serialization.go
@@ -0,0 +1,90 @@
+package vm
+
+import (
+	"errors"
+
+	"github.com/CityOfZion/neo-go/pkg/io"
+)
+
+type stackItemType byte
+
+const (
+	byteArrayT stackItemType = 0x00
+	booleanT   stackItemType = 0x01
+	integerT   stackItemType = 0x02
+	arrayT     stackItemType = 0x80
+	structT    stackItemType = 0x81
+	mapT       stackItemType = 0x82
+)
+
+func serializeItem(item StackItem) ([]byte, error) {
+	w := io.NewBufBinWriter()
+	serializeItemTo(item, w.BinWriter)
+	if w.Err != nil {
+		return nil, w.Err
+	}
+	return w.Bytes(), nil
+}
+
+func serializeItemTo(item StackItem, w *io.BinWriter) {
+	switch t := item.(type) {
+	case *ByteArrayItem:
+		w.WriteLE(byte(byteArrayT))
+		w.WriteBytes(t.value)
+	case *BoolItem:
+		w.WriteLE(byte(booleanT))
+		w.WriteLE(t.value)
+	case *BigIntegerItem:
+		w.Err = errors.New("not implemented")
+	case *InteropItem:
+		w.Err = errors.New("not supported")
+	case *ArrayItem:
+		w.Err = errors.New("not implemented")
+	case *StructItem:
+		w.Err = errors.New("not implemented")
+	case *MapItem:
+		w.Err = errors.New("not implemented")
+	}
+}
+
+func deserializeItem(data []byte) (StackItem, error) {
+	r := io.NewBinReaderFromBuf(data)
+	item := deserializeItemFrom(r)
+	if r.Err != nil {
+		return nil, r.Err
+	}
+	return item, nil
+}
+
+func deserializeItemFrom(r *io.BinReader) StackItem {
+	var t byte
+	r.ReadLE(&t)
+	if r.Err != nil {
+		return nil
+	}
+
+	switch stackItemType(t) {
+	case byteArrayT:
+		data := r.ReadBytes()
+		return NewByteArrayItem(data)
+	case booleanT:
+		var b bool
+		r.ReadLE(&b)
+		return NewBoolItem(b)
+	case integerT:
+		r.Err = errors.New("not implemented")
+		return nil
+	case arrayT:
+		r.Err = errors.New("not implemented")
+		return nil
+	case structT:
+		r.Err = errors.New("not implemented")
+		return nil
+	case mapT:
+		r.Err = errors.New("not implemented")
+		return nil
+	default:
+		r.Err = errors.New("unknown type")
+		return nil
+	}
+}
diff --git a/pkg/vm/vm.go b/pkg/vm/vm.go
index 568e47110..0fb917883 100644
--- a/pkg/vm/vm.go
+++ b/pkg/vm/vm.go
@@ -86,6 +86,10 @@ func New() *VM {
 	// Register native interop hooks.
 	vm.RegisterInteropFunc("Neo.Runtime.Log", runtimeLog, 1)
 	vm.RegisterInteropFunc("Neo.Runtime.Notify", runtimeNotify, 1)
+	vm.RegisterInteropFunc("Neo.Runtime.Serialize", runtimeSerialize, 1)
+	vm.RegisterInteropFunc("System.Runtime.Serialize", runtimeSerialize, 1)
+	vm.RegisterInteropFunc("Neo.Runtime.Deserialize", runtimeDeserialize, 1)
+	vm.RegisterInteropFunc("System.Runtime.Deserialize", runtimeDeserialize, 1)
 
 	return vm
 }
diff --git a/pkg/vm/vm_test.go b/pkg/vm/vm_test.go
index 7eeb04a63..a8d94f1e1 100644
--- a/pkg/vm/vm_test.go
+++ b/pkg/vm/vm_test.go
@@ -197,6 +197,54 @@ func TestPushData4Good(t *testing.T) {
 	assert.Equal(t, []byte{1, 2, 3}, vm.estack.Pop().Bytes())
 }
 
+func getSyscallProg(name string) (prog []byte) {
+	prog = []byte{byte(SYSCALL)}
+	prog = append(prog, byte(len(name)))
+	prog = append(prog, name...)
+
+	return
+}
+
+func getSerializeProg() (prog []byte) {
+	prog = append(prog, getSyscallProg("Neo.Runtime.Serialize")...)
+	prog = append(prog, getSyscallProg("Neo.Runtime.Deserialize")...)
+	prog = append(prog, byte(RET))
+
+	return
+}
+
+func testSerialize(t *testing.T, vm *VM) {
+	err := vm.Step()
+	require.NoError(t, err)
+	require.Equal(t, 1, vm.estack.Len())
+	require.IsType(t, (*ByteArrayItem)(nil), vm.estack.Top().value)
+
+	err = vm.Step()
+	require.NoError(t, err)
+	require.Equal(t, 1, vm.estack.Len())
+}
+
+func TestSerializeBool(t *testing.T) {
+	vm := load(getSerializeProg())
+	vm.estack.PushVal(true)
+
+	testSerialize(t, vm)
+
+	require.IsType(t, (*BoolItem)(nil), vm.estack.Top().value)
+	require.Equal(t, true, vm.estack.Top().Bool())
+}
+
+func TestSerializeByteArray(t *testing.T) {
+	vm := load(getSerializeProg())
+	value := []byte{1, 2, 3}
+	vm.estack.PushVal(value)
+
+	testSerialize(t, vm)
+
+	require.IsType(t, (*ByteArrayItem)(nil), vm.estack.Top().value)
+	require.Equal(t, value, vm.estack.Top().Bytes())
+}
+
 func callNTimes(n uint16) []byte {
 	return makeProgram(
 		PUSHBYTES2, Instruction(n), Instruction(n>>8), // little-endian