diff --git a/acme/error.go b/acme/error.go
index 6d7013cf..e4bc934c 100644
--- a/acme/error.go
+++ b/acme/error.go
@@ -8,7 +8,10 @@ import (
 	"strings"
 )
 
-const tosAgreementError = "Must agree to subscriber agreement before any further actions"
+const (
+	tosAgreementError = "Must agree to subscriber agreement before any further actions"
+	invalidNonceError = "JWS has invalid anti-replay nonce"
+)
 
 // RemoteError is the base type for all errors specific to the ACME protocol.
 type RemoteError struct {
@@ -28,6 +31,12 @@ type TOSError struct {
 	RemoteError
 }
 
+// NonceError represents the error which is returned if the
+// nonce sent by the client was not accepted by the server.
+type NonceError struct {
+	RemoteError
+}
+
 type domainError struct {
 	Domain string
 	Error  error
@@ -73,6 +82,10 @@ func handleHTTPError(resp *http.Response) error {
 		return TOSError{errorDetail}
 	}
 
+	if errorDetail.StatusCode == http.StatusBadRequest && strings.HasPrefix(errorDetail.Detail, invalidNonceError) {
+		return NonceError{errorDetail}
+	}
+
 	return errorDetail
 }
 
diff --git a/acme/jws.go b/acme/jws.go
index 4818f17e..876b39b7 100644
--- a/acme/jws.go
+++ b/acme/jws.go
@@ -41,15 +41,26 @@ func (j *jws) post(url string, content []byte) (*http.Response, error) {
 	}
 
 	resp, err := httpPost(url, "application/jose+json", bytes.NewBuffer([]byte(signedContent.FullSerialize())))
-	if err != nil {
-		return nil, err
-	}
 
+	// Even in case of an error, the response should still contain a nonce.
 	nonce, nonceErr := getNonceFromResponse(resp)
 	if nonceErr == nil {
 		j.nonces.Push(nonce)
 	}
 
+	if err != nil {
+		switch err.(type) {
+		case NonceError:
+			// In case of a nonce error - retry once
+			resp, err = httpPost(url, "application/jose+json", bytes.NewBuffer([]byte(signedContent.FullSerialize())))
+			if err != nil {
+				return nil, err
+			}
+		default:
+			return nil, err
+		}
+	}
+
 	return resp, err
 }