diff --git a/cmd/zz_gen_cmd_dnshelp.go b/cmd/zz_gen_cmd_dnshelp.go
index 6a9d7d75..1ca1e203 100644
--- a/cmd/zz_gen_cmd_dnshelp.go
+++ b/cmd/zz_gen_cmd_dnshelp.go
@@ -1450,7 +1450,9 @@ func displayDNSHelp(name string) error {
 		ew.writeln(`Credentials:`)
 		ew.writeln(`	- "AWS_ACCESS_KEY_ID":	Managed by the AWS client ('AWS_ACCESS_KEY_ID_FILE' is not supported)`)
 		ew.writeln(`	- "AWS_HOSTED_ZONE_ID":	Override the hosted zone ID`)
+		ew.writeln(`	- "AWS_PROFILE":	Managed by the AWS client ('AWS_PROFILE_FILE' is not supported)`)
 		ew.writeln(`	- "AWS_REGION":	Managed by the AWS client ('AWS_REGION_FILE' is not supported)`)
+		ew.writeln(`	- "AWS_SDK_LOAD_CONFIG":	Retrieve the region from the CLI config file ('AWS_SDK_LOAD_CONFIG_FILE' is not supported)`)
 		ew.writeln(`	- "AWS_SECRET_ACCESS_KEY":	Managed by the AWS client ('AWS_SECRET_ACCESS_KEY_FILE' is not supported)`)
 		ew.writeln()
 
diff --git a/docs/content/dns/zz_gen_route53.md b/docs/content/dns/zz_gen_route53.md
index 91c538f0..f28d4cbf 100644
--- a/docs/content/dns/zz_gen_route53.md
+++ b/docs/content/dns/zz_gen_route53.md
@@ -31,7 +31,9 @@ _Please contribute by adding a CLI example._
 |-----------------------|-------------|
 | `AWS_ACCESS_KEY_ID` | Managed by the AWS client (`AWS_ACCESS_KEY_ID_FILE` is not supported) |
 | `AWS_HOSTED_ZONE_ID` | Override the hosted zone ID |
+| `AWS_PROFILE` | Managed by the AWS client (`AWS_PROFILE_FILE` is not supported) |
 | `AWS_REGION` | Managed by the AWS client (`AWS_REGION_FILE` is not supported) |
+| `AWS_SDK_LOAD_CONFIG` | Retrieve the region from the CLI config file (`AWS_SDK_LOAD_CONFIG_FILE` is not supported) |
 | `AWS_SECRET_ACCESS_KEY` | Managed by the AWS client (`AWS_SECRET_ACCESS_KEY_FILE` is not supported) |
 
 The environment variable names can be suffixed by `_FILE` to reference a file instead of a value.
@@ -54,16 +56,22 @@ More information [here](/lego/dns/#configuration-and-credentials).
 
 AWS Credentials are automatically detected in the following locations and prioritized in the following order:
 
-1. Environment variables: `AWS_ACCESS_KEY_ID`, `AWS_SECRET_ACCESS_KEY`, `AWS_REGION`, [`AWS_SESSION_TOKEN`]
-2. Shared credentials file (defaults to `~/.aws/credentials`)
+1. Environment variables: `AWS_ACCESS_KEY_ID`, `AWS_SECRET_ACCESS_KEY`, [`AWS_SESSION_TOKEN`]
+2. Shared credentials file (defaults to `~/.aws/credentials`, profiles can be specified using `AWS_PROFILE`)
 3. Amazon EC2 IAM role
 
+The AWS Region is automatically detected in the following locations and prioritized in the following order:
+
+1. Environment variables: `AWS_REGION`
+2. Shared configuration file if `AWS_SDK_LOAD_CONFIG` is set (defaults to `~/.aws/config`, profiles can be specified using `AWS_PROFILE`)
+
 If `AWS_HOSTED_ZONE_ID` is not set, Lego tries to determine the correct public hosted zone via the FQDN.
 
 See also:
 
 - [sessions](https://docs.aws.amazon.com/sdk-for-go/v1/developer-guide/sessions.html)
-- [Setting AWS Credentials](https://docs.aws.amazon.com/sdk-for-java/v1/developer-guide/setup-credentials.html#setup-credentials-setting)
+- [Setting AWS Credentials](https://docs.aws.amazon.com/sdk-for-go/v1/developer-guide/configuring-sdk.html#specifying-credentials)
+- [Setting AWS Region](https://docs.aws.amazon.com/sdk-for-go/v1/developer-guide/configuring-sdk.html#specifying-the-region)
 
 ## Policy
 
diff --git a/providers/dns/route53/route53.toml b/providers/dns/route53/route53.toml
index 7fd70937..797d21a4 100644
--- a/providers/dns/route53/route53.toml
+++ b/providers/dns/route53/route53.toml
@@ -11,16 +11,22 @@ Additional = '''
 
 AWS Credentials are automatically detected in the following locations and prioritized in the following order:
 
-1. Environment variables: `AWS_ACCESS_KEY_ID`, `AWS_SECRET_ACCESS_KEY`, `AWS_REGION`, [`AWS_SESSION_TOKEN`]
-2. Shared credentials file (defaults to `~/.aws/credentials`)
+1. Environment variables: `AWS_ACCESS_KEY_ID`, `AWS_SECRET_ACCESS_KEY`, [`AWS_SESSION_TOKEN`]
+2. Shared credentials file (defaults to `~/.aws/credentials`, profiles can be specified using `AWS_PROFILE`)
 3. Amazon EC2 IAM role
 
+The AWS Region is automatically detected in the following locations and prioritized in the following order:
+
+1. Environment variables: `AWS_REGION`
+2. Shared configuration file if `AWS_SDK_LOAD_CONFIG` is set (defaults to `~/.aws/config`, profiles can be specified using `AWS_PROFILE`)
+
 If `AWS_HOSTED_ZONE_ID` is not set, Lego tries to determine the correct public hosted zone via the FQDN.
 
 See also:
 
 - [sessions](https://docs.aws.amazon.com/sdk-for-go/v1/developer-guide/sessions.html)
-- [Setting AWS Credentials](https://docs.aws.amazon.com/sdk-for-java/v1/developer-guide/setup-credentials.html#setup-credentials-setting)
+- [Setting AWS Credentials](https://docs.aws.amazon.com/sdk-for-go/v1/developer-guide/configuring-sdk.html#specifying-credentials)
+- [Setting AWS Region](https://docs.aws.amazon.com/sdk-for-go/v1/developer-guide/configuring-sdk.html#specifying-the-region)
 
 ## Policy
 
@@ -61,6 +67,8 @@ The following AWS IAM policy document describes the permissions required for leg
     AWS_SECRET_ACCESS_KEY = "Managed by the AWS client (`AWS_SECRET_ACCESS_KEY_FILE` is not supported)"
     AWS_REGION = "Managed by the AWS client (`AWS_REGION_FILE` is not supported)"
     AWS_HOSTED_ZONE_ID = "Override the hosted zone ID"
+    AWS_PROFILE = "Managed by the AWS client (`AWS_PROFILE_FILE` is not supported)"
+    AWS_SDK_LOAD_CONFIG = "Retrieve the region from the CLI config file (`AWS_SDK_LOAD_CONFIG_FILE` is not supported)"
   [Configuration.Additional]
     AWS_MAX_RETRIES = "The number of maximum returns the service will use to make an individual API request"
     AWS_POLLING_INTERVAL = "Time between DNS propagation check"